If the patient has stones inside the gallbladder, it may lead to inflammation of the mucosa of the gallbladder, which will lead to hidden pain and distension in the upper abdomen or right upper abdomen. When the patient eats greasy food, it may induce acute inflammation of the gallbladder, which is usually caused by bacterial infection, usually with E. coli bacteria, and the patient’s pain is significantly increased because of the thickening of the gallbladder wall and oozing around the gallbladder. If the patient’s gallbladder stones are embedded in the opening of the gallbladder, that is, the location of the jugular abdomen of the gallbladder, resulting in obstruction of the opening of the gallbladder, it will lead to enlargement of the gallbladder, the gallbladder has fluid, in this case, the pain of the gallbladder is more pronounced, and if necessary, need to undergo emergency surgical treatment, also need to transfuse antibiotics to alleviate the inflammation of the gallbladder, but also can be used to alleviate the pain of the pain medication for a short period of time.