Post-holiday syndrome is a variety of physical or psychological manifestations of people after a long period of vacation, such as feeling fed up in the two or three days after the holiday, unable to lift their spirits, low work efficiency at work, and even unexplained nausea, dizziness, intestinal reactions, anorexia nervosa, anxiety, neurasthenia and other conditions, which can be improved through regular life and other ways. Post-holiday syndrome is mostly seen in some long-term in the high-intensity work and study under the adults and students, the treatment method first of all to let this kind of people from the ideological preparation for work and study, and then gradually adapted to the intensity of work and study. Secondly, post-holiday syndrome can be improved by regular lifestyle, rationalize the arrangement of daily life, make their own life regular, especially the older patients, the muscle regulation function decreases, during the holiday more attention to maintain a good life routine.