The etiology and pathogenesis of restless legs are not clear, and may be related to genetics, diseases, substance deficiencies and other factors. 1. Genetic factors: generally 55% to 90% of people with restless legs have positive family history, usually autosomal dominant. 2. Disease factors: endocrine disorders, bleeding disorders, etc., can trigger the symptoms of restless legs. 3. Substance deficiencies: iron deficiency can cause dysfunction of the dopamine system, thus triggering the symptoms of restless legs. 4. Others: low nutrition, bad habits, low immunity, etc. can lead to restless legs symptoms. If you have discomfort in the lower limbs at night, you should consult a doctor in time and standardize the treatment to avoid delaying the condition.