Whether urinary protein 2+ need to do nephropuncture mainly depends on the cause of urinary protein. If it is caused by physiological reasons such as fever, strenuous exercise, etc., the urine protein can turn negative by itself after rest, usually do not need to do renal puncture; if it is caused by pathologic reasons such as nephrotic syndrome, glomerulonephritis, etc., it may be necessary to do renal puncture to clarify the type of pathology and guide the treatment. 1. Physiological reasons: physiological proteinuria is more common in cases of strenuous exercise, fever, etc. The patient’s kidneys do not have organic lesions, so there is no need for special treatment, and the protein in the urine can turn negative by itself after resting, so there is no need to do renal puncture. 2. Pathological causes: such as nephrotic syndrome, glomerulonephritis, etc., the integrity of glomerular filtration membrane is damaged, permeability is reduced, and urine protein appears. Renal puncture is feasible in the absence of contraindications to clarify the type of pathology and guide subsequent treatment. If the patient found that the urine protein 2 +, it is recommended to go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.