The first time to take Irbesartan blood pressure is not stable, usually can temporarily add captopril. Irbesartan is mainly used in the treatment of primary hypertension, or combined with type 2 diabetic nephropathy and other diseases, enalapril is mainly used in the treatment of primary hypertension and other diseases; if you just start taking irbesartan treatment, the blood pressure is not controlled in the ideal range, usually can be temporarily added to captopril to lower blood pressure treatment. Usually captopril belongs to the short-acting blood pressure-lowering drugs, after taking about 1 hour can reach the peak concentration of the drug, so as to play the effect of lowering blood pressure; therefore, after the addition of captopril antihypertensive treatment, can enhance the intensity of Irbesartan’s blood pressure lowering as well as prolonged lowering of blood pressure time, which is conducive to the control of blood pressure in a short period of time in the ideal range. Secondly, Irbesartan may cause postural dizziness, hypotension, skeletal muscle pain and other discomforts after use, and for severe renal function abnormalities, hyperkalemia, pregnant women, lactating women are prohibited; in the process of using the drug also need to monitor the blood pressure and liver and kidney function, for the elderly and other special groups, need to be guided by a doctor to use the drug. Captopril may cause dizziness, headache, drowsiness and other symptoms, and for renal artery stenosis, renal transplantation and allergic to the drug ingredients patients are prohibited, for pregnant and lactating women and other special groups, need to be under the guidance of a doctor to use the drug. All of the above medications should be used under the guidance of a doctor, avoid self-medication, in order to avoid adverse consequences.