IVF megacolon should be dealt with according to the individual’s situation by choosing conservative treatment, surgical treatment to deal with. In vitro fertilization (IVF), megacolon is congenital megacolon, which is due to the lack of colonic ganglion cells causing continuous spasm of the intestinal tube, fecal stasis in the proximal colon, resulting in proximal bowel enlargement or dilatation, and children born with delayed evacuation of the fetal stools, abdominal distension, flatulence and other uncomfortable symptoms. Conservative treatment includes regular isotonic salt cleansing of the intestines, dilation of the anal canal, and the use of corkscrews or laxatives to help laxation, so as to avoid the stagnation of stool in the colon and aggravate the constipation symptoms. Through the conservative treatment effect is not good patients, and then consider surgery to treat the disease, such as short-segment type megacolon patients, consider the megacolon resection surgery to deal with. In vitro fertilization megacolon should seek timely medical treatment, long time without treatment will affect the normal development of the baby.