The current clinical first-line antidepressants have very little effect on sexual function, but the specific situation should be analyzed, especially the current situation of the old drugs, commonly used tricyclic and tetracyclic antidepressants, such as clomipramine, doxepin, maprotiline, nortriptyline and other drugs, there may also be significant effects on the endocrine system, metabolic system, for example, can cause increased lactogen, sexual dysfunction, men gynecomastia, or amenorrhea in women, etc. So there are possible effects on sexual function in both men and women. Newer antidepressants, such as sertraline, etc., may also have side effects of delayed ejaculation when taken for long periods of time. These cases are relatively rare, but it is important to follow medical advice to effectively avoid side effects.