Metronidazole can treat periodontitis, but plays an auxiliary therapeutic role, and can not rely solely on metronidazole cure. 1. Metronidazole is widely used in the treatment of anaerobic infections, nitroimidazole drugs, periodontitis can be taken orally, systemic drug therapy, the purpose is to kill anaerobic bacteria in the periodontal pockets, eliminating the infection, to avoid recurrence. However, it should be noted that pregnant and lactating women, as well as patients with renal insufficiency need to be used with caution. 2. periodontitis if the acute stage, mostly accompanied by periodontal abscess formation, need to incise and drain pus, and then to be used to control the infection, gingival scaling or subgingival scraping to remove tartar, plaque, to maintain oral hygiene and cleanliness. If the degree of periodontitis is more serious, it is necessary to consider gingival flap surgery, bone grafting and other treatments. It is recommended that patients with periodontitis seek medical treatment in a timely manner, and the use of medication should follow the doctor’s instructions.