Cerebral blood supply insufficiency may cause generalized weakness, which is mainly related to cerebral ischemia and hypoxia, and may be due to the combination of hypoglycemia, anemia and other problems. 1. Cerebral ischemia and hypoxia: when suffering from cerebral blood supply insufficiency, the symptoms of generalized weakness appear due to cerebral ischemia and hypoxia, which may be accompanied by numbness and other symptoms. It is recommended to combine with intracranial Doppler examination, cerebral angiography and other diagnostic examinations to clarify. 2. Combined with hypoglycemia: when the patient is combined with hypoglycemia, due to the decrease of glucose in the human body, generalized weakness may appear, and even symptoms such as cold sweat and limb twitching may appear. 3. Combined with anemia: when combined with anemia, due to the reduction of hemoglobin in the blood, the oxygen content in the blood of the human body decreases, which leads to a lack of oxygen in the brain, and generalized weakness will also occur, accompanied by symptoms such as pallor. It is recommended to consult a doctor if the patient has frequent symptoms of generalized weakness.