Generally speaking, it is difficult to cure advanced rectal cancer, and clinically there is no saying that “advanced rectal cancer is actually cured”. Patients with advanced rectal cancer should adjust their mentality and actively cooperate with doctor’s treatment. Rectal cancer is a malignant tumor originated from epithelial cells of rectal mucosa. Patients with advanced rectal cancer may have abdominal pain, abdominal distension, pus and blood in stool, etc. When the tumor develops metastasis, symptoms such as ascites, cough, cerebral embolism, pathological fracture, etc., and malignant fluid manifestations such as severe anemia, extreme emaciation, and even death, etc., can also occur. The condition of patients with advanced rectal cancer is more serious and develops rapidly, which is usually difficult to be cured, and its treatment mainly focuses on prolonging patients’ life and improving the quality of survival. Patients with advanced rectal cancer can effectively improve the prognosis of the disease through early detection, early diagnosis and early treatment. Patients with advanced stage can improve the survival rate and prolong the survival period through chemotherapy, radiotherapy and other treatments, as appropriate, to provide appropriate relief for the condition, and then undergo surgery. Patients with advanced stage of rectal cancer should not blindly expect the condition to improve on its own, but should consult the doctor in time and get standardized treatment by the doctor, meanwhile, strengthen nutrition and keep optimistic mentality.