There is no very fast way to reduce the swelling of pyriform myxedema, and a combination of intravenous anti-inflammatory drugs and dehydration drugs can be used to reduce the swelling. Piriformis edema is one of the symptoms of pyriformis syndrome, which often causes sciatica and unilateral lower limb paralysis or pain. Piriformis syndrome should be followed by adequate rest, after which it is recommended to go to the hospital for an imaging test to clarify the musculoskeletal relationship. If it is clear that the pyriformis muscle is hyperplastic, then surgical decompression should be performed to prevent the pyriformis muscle from further compressing the nerve. If simple pyriform muscle edema, then intravenous anti-inflammatory drugs and dehydration drugs should be injected to reduce the degree of inflammatory reaction in the body and reduce pyriform muscle edema. The main way to reduce the swelling of the pyriform muscle is to use intravenous anti-inflammatory drugs and dehydration drugs to reduce the compression of the sciatic nerve, which in turn reduces the pain. If pyriform edema is not relieved by rest, please go to the hospital and follow the doctor’s instructions.