Patient: Extensive hysterectomy + double adnexal resection + pelvic and abdominal aortic lymph node dissection was done on May 2, 2011. Postoperative peritoneal washings: proliferating mesothelial cells were seen, and a few neutrophils and lymphocytes were seen, no other abnormalities were seen. Postoperative pathological findings: 1. The uterine body was 9×6×2.5 cm in size and the uterine cavity was filled with a cauliflower-like mass of 5×3×2.5 cm in size, which was fragile and easy to dislodge, as seen by the naked eye. 2, Endometrioid adenocarcinoma, moderately differentiated, invading the superficial muscular layer, with no involvement of the cervical canal, cervix and vaginal wall cut edges. 11 groups of lymph nodes sent did not show cancer metastasis (0/40). 3, Bilateral ovarian white bodies, bilateral tubal chronic inflammation, no cancer involvement was seen. 4.Immunohistochemistry: CK5/6(-) CK8(+) ER(+>90%) PR(+>90%) Ki67(+70%) P53(+) Help wanted: 1.Since the attending doctor did not inform the stage, I would like to know if my mother’s surgical stage is stage Ib G2? 2.Is this serious and what is the prognosis? Does that moderate differentiation affect the prognosis very much? 3. Since I don’t know anything about immunohistochemistry, what is the result of this immunohistochemistry? Hospital Hello! 1. “Endometrioid adenocarcinoma, moderately differentiated, invading superficial muscular layer” used to be stage Ib G2, according to 2011 NCCN new surgical staging, it should be stage Ia G2. 2. Prognosis is good, five-year survival rate is 90%, moderate differentiation is not very influential on prognosis. 3. CK5/6(-) CK8(+) is an auxiliary diagnosis, glandular epithelium mainly expresses CK8, while squamous epithelium mainly expresses CK5/6. ER, PR positive patients indicate better differentiation of tumor cells, Ki67, p53 and patient’s prognosis correlate, high positivity rate represents poor prognosis. Immunohistochemical results are for reference only.