The main adverse effects of hydrocortisone acetate tablets include weight gain, nausea, osteoporosis, and fractures. Hydrocortisone acetate tablets have anti-inflammatory, immunosuppressive, and anti-allergic effects, and are commonly used in the treatment of congenital adrenocortical hyperplasia, and in the replacement therapy of hypoadrenocorticism. Some people may experience adverse reactions after using the drug, mainly weight gain, swelling of the lower limbs, and gastrointestinal irritation such as nausea and vomiting, and some people may also experience osteoporosis as well as bone fracture. If you need to use hydrocortisone acetate tablets, it is recommended to use the drug under the guidance of a doctor to avoid unauthorized use. It should be noted that it is contraindicated for those who are allergic to this product and other steroid hormones.