The cause of the uncomfortable feeling of blockage in the middle of the chest is considered to be caused by the following aspects: First, it is considered to be caused by the cardiovascular system diseases of the body. Mostly due to the usual coronary heart disease or exertional angina, as well as myocardial ischemia and other underlying medical history, coupled with the recent work strain or emotional excitement, resulting in increased oxygen supply to the body, which in turn increases the burden on the heart, causing the middle of the chest feeling blocked uncomfortable. It is necessary to go to the cardiology department of the hospital and have an electrocardiogram and cardiac ultrasound to clarify. In addition, we should pay attention to rest, and at the same time take drugs to nourish the heart muscle and improve blood supply to the heart muscle. The second cause is due to respiratory system diseases. Mainly including spontaneous pneumothorax as well as rupture of pulmonary blisters, acute and chronic bronchitis, etc., all may also cause uncomfortable blockage in the middle of the chest. However, respiratory system diseases are usually accompanied by cough, cough and other respiratory symptoms, which can be clarified by performing chest CT examination. The third cause is due to intercostal nerve pain, which can be treated with nerve-nourishing drugs.