Cystic solid nodules with calcification in the right lobe of the thyroid gland can be treated with medications and surgery. If the cystic solid nodule in the right lobe of the thyroid gland has been excluded from malignancy by puncture biopsy or other means, is small in size, does not cause compression of the nerves or other structures, and has a small area of calcification, it can be treated with medication or observed and followed up for review. Since there is a tendency of malignant changes in cystic solid nodular changes in the right lobe of the thyroid gland, if the patient’s benign or malignant nature is uncertain, it is recommended to take pathologic sections through surgery to clearly diagnose the benign or malignant nature of the disease. If it is malignant or benign but large, treatment by thyroidectomy or partial thyroidectomy is recommended. If it is malignant, radiotherapy and chemotherapy may also be needed. It is recommended that the patient seek timely medical attention and choose the appropriate treatment plan under the guidance of the doctor.