High gamma-glutamyltransferase can be caused by physiological reasons such as staying up late at night and pathologic reasons such as liver diseases. Physiological factors do not require special treatment, while pathologic causes need to be treated according to the doctor’s instructions for the primary disease. 1. Physiological reasons: if you stay up late, drink a lot of alcohol, or exercise strenuously before the test, it will lead to high gamma-glutamyltransferase. There is no need to be overly nervous in such cases. Generally speaking, if the test is conducted after eliminating these triggers, the γ-glutamyltransferase will drop and return to the normal level. 2. Pathological reasons: If you suffer from acute and chronic viral hepatitis, cirrhosis, fatty liver, alcoholic liver, drug liver damage, it will lead to high γ-glutamyltransferase. Patients should be treated for the primary disease. If viral hepatitis is present, liver-protecting and enzyme-lowering drugs (e.g. glycyrrhizic acid preparation, etc.) and antiviral drugs (e.g. entecavir, etc.) can be taken according to the doctor’s instruction, so as to make the γ-glutamyltransferase decrease. It should be reminded that if γ-glutamyltransferase is found to be high, it is recommended to consult a doctor in time for further examination to determine the cause of the disease, and then according to the cause of the symptomatic treatment. In addition, usually should develop good habits, light diet, avoid excessive alcohol consumption, appropriate exercise.