Progesterone does not cause estradiol to rise or fall. Progesterone is a steroid hormone secreted by ovaries, placenta and adrenal glands, which can change the endometrium from proliferative phase to secretory phase, providing a better condition for the implantation of the fertilized egg; meanwhile, it can reduce the excitability of the uterus in pregnancy after the implantation of the fertilized egg, and it is mainly used in the treatments for the illnesses of preterm miscarriage and habitual miscarriage. Usually, this drug does not affect the level of estradiol during the process of taking, and can effectively improve the efficacy of functional uterine bleeding when used in combination with estradiol, and the adverse effects are relatively small. Secondly, it is prohibited for those who are allergic to the components of the drug, those who have unexplained vaginal bleeding, and those who have vascular embolism; in the process of taking the drug, it is necessary to pay attention to monitoring the liver function and breast examination, and pregnant women and breastfeeding women should use the drug under the guidance of a doctor. If you need to use the drug is recommended under the guidance of a doctor, do not blindly self-medication, in order to avoid adverse effects.