High biochemical creatinine and high blood glucose may be caused by abnormal kidney function and reduced insulin secretion, respectively, and require targeted treatment for both diseases. In addition, it is also necessary to pay attention to find the reasons for the elevation of these two indicators, and whether they have any influence on each other. 1. High creatinine caused by abnormal renal function: the cause of abnormal renal function should be determined by combining the results of routine urinalysis, urinary ultrasound and other examinations, and if necessary, creatinine-lowering drugs, such as prednisone, cyclophosphamide, urethane granules and so on, should be taken on the advice of the doctor. 2. High blood sugar due to lowered insulin secretion: High blood sugar is caused by lowered insulin secretion in the body, and it is recommended to combine with the results of glucose tolerance and other tests to determine whether it is diabetes or not. Normally, you should pay attention to consume less sugary food, and if necessary, you can use hypoglycemic drugs such as insulin under the guidance of doctor. High creatinine and blood glucose in biochemical examination may suggest mild abnormalities in kidney function and weakened insulin secretion, it is recommended to go to the hospital in time, under the guidance of the doctor, to make a clear diagnosis and then timely targeted treatment.