The early manifestations of leukemia leg pain include localized pain, usually without fever, redness and swelling, mostly occurring in the joints, and pain lasting for a long time. Leukemia leg pain is one of the early manifestations of leukemia, and it can be the only symptom in the early stage in acute lymphoblastic leukemia. The general pain site is the long bones, such as the involvement of the femur when the pain is intense, like a knife cut. Some patients with leg pain is a side effect of the use of a large number of hormones in the process of leukemia treatment, it is difficult to self-relieve or the use of drugs to relieve, generally need to use aminophenol hydrocodone, morphine, etc. for analgesic treatment. In addition, the early symptoms of leukemia are fever, anemia, infection and so on. If the patient has unexplained fever, and the high fever persists, and drug treatment is ineffective, to consider the possibility of leukemia. In severe cases, there will also be bleeding manifestations in the nasal cavity, mouth, intracranial and other parts of the body, as well as angina, dyspnea and other symptoms. Leukemia leg pain early symptoms are obvious, pain is intolerable, after the emergence of should be early to the hospital under the guidance of the physician for treatment, to avoid affecting the normal life of patients or lead to disease progression.