The main cause of chest tightness and irritability is anxiety disorder, which is clinically characterized by excessive worry, fear, and difficulty in predicting the future, so the patient is fearful, terrified, and has a strong inner experience of worry. At this time, the patient has a physical reaction, chest tightness, shortness of breath, and the patient’s heartbeat accelerated, at this time, the patient has uncertainty about the past or the future to express concern, irritability, walking back and forth, there is a physical discomfort experience, and the patient’s arousal is relatively high, manifested as abnormal excitement, anxiety. The patient’s sympathetic-type nervous system function is hyperactive at this time, and there is muscle tension and a series of unusual changes that include the cardiovascular system, the nervous system, the genitourinary system, the digestive system, and the skin system. So these changes cause the patient to become more fearful, worried, irritable, and the chest tightness is also more aggravated. So after the diagnosis of anxiety disorder, you can apply anti-anxiety drug systematic treatment, can achieve good therapeutic effect, such as the application of benzodiazepine anxiolytics and new antidepressants can achieve good results.