The presence of diarrhea in urticaria is usually due to the irritative reaction caused by the edematous, edema-like erythema of the abdominal gastrointestinal mucosa due to urticaria, which is usually a sterile inflammatory reaction. When no corresponding leukocyte infection is seen during routine stool tests, it is necessary to administer pantoprazole injection or omeprazole injection to protect the gastrointestinal mucosa. At the same time, anti-allergy treatment should be combined with oral administration of olopatadine hydrochloride and fexofenadine hydrochloride tablets to enhance anti-allergy and anti-itch treatment. If the efficacy is not yet satisfactory, dexamethasone sodium phosphate injection can be given intramuscularly to strengthen the anti-allergic and immunosuppressive effect, while raw, cold and hard foods should be avoided during treatment.