Cranial defect is a very common disorder in neurosurgical clinics, which can often be caused by trauma such as traffic accidents, production safety accidents, falling from height, or left after craniotomy for intracranial tumors, cerebral hemorrhage, and other cranial diseases itself. What is the damage to the brain caused by cranial defects? The harm of cranial defect lies in destroying the integrity of the skull, the closure of the cranial cavity and the stability of the intracranial environment, thus causing cerebrospinal fluid circulation and blood circulation obstacles, affecting the normal operation of the nerve function and causing a series of neurological symptoms. Some patients may show dizziness, headache, limb weakness, poor fine activities, weakened vision, emotional instability, irritability and so on. Therefore, to carry out cranial bone repair, cranial bone defect repair, one is to choose the excellent performance of the repair material, the second is the surgical operation skills also have high requirements. At present, there is a new type of special polymer material – polyether ether ketone PEEK material, performance is very excellent, PEEK material does not conduct heat, the patient will not be afraid of heat and cold, in addition to the hardness, stiffness, strength, elasticity, histocompatibility, etc. PEEK material and the autologous cranial bone are comparable to the titanium mesh, which can be very well overcome the various problems that may arise from the material. In addition, the hardness, stiffness, strength, elasticity, and tissue compatibility of PEEK material are comparable to those of autologous skull, which can overcome the problems of titanium mesh and become the new trend of cranial bone repair material. We are currently using this advanced PEEK material and have excellent surgical skills. The team constantly improves and upgrades the technology and optimizes the design of the material, and currently has 4 technological innovations, and innovatively introduces the concept of cosmetic plastic surgery, so as to comprehensively carry out PEEK cranial bone repair and plastic surgery, which can achieve the organic unity of anatomical integrity, perfect function, and beautiful appearance, and has been highly praised by the majority of patients and their families and praises.