The first thing to do is to determine whether the pain in the middle of the chest is caused by physiological factors, such as overexertion or localized pressure, etc. If physiological factors are excluded, it is necessary to consider the causes of diseases, such as reflux esophagitis, osteoarthritis, tumors, and traumas. 1. Physiological factors (1) Overexertion: The increased load of the body after overexertion will cause lactic acid accumulation in the surrounding muscles after exercise, resulting in pressure pain. (2) Local compression: Wearing clothes too tightly or compressing local tissues during sleep will also lead to localized slight compression pain. 2. Pathologic factors (1) Reflux esophagitis: the abnormal function of cardia causes gastroesophageal reflux, and the gastric acid in the cardia will burn the esophageal mucosa and cause pressing pain. (2) Osteoarthritis: mainly related to osteochondritis, intercostal neuralgia, etc., and aseptic inflammation in the surrounding area will cause pressure pain. (3) Tumor: mainly including mediastinal tumor and intrapulmonary tumor invading the surrounding pleura, stimulating the nerves and causing pain during compression. (4) Trauma: the appearance of chest trauma, causing the surrounding edema, oozing, can also cause the manifestation of local pressing pain. If the pain is obvious and cannot be relieved, it is necessary to consult a doctor for observation and standardized treatment after diagnosing the specific condition.