Fatigue of the inner thighs and calves may be related to physiological factors such as exercise and exertion, as well as pathological factors such as lumbar spine lesions and vascular lesions. 1. Physiological factors: when strenuous exercise, prolonged heavy labor, can lead to lower limb muscle fatigue, the body produces excessive metabolic products, lactic acid accumulation, can cause thigh and calf muscle pain and fatigue and weakness. 2. Lumbar spine lesions: such as lumbar disc herniation, spinal stenosis and other lumbar spine diseases, due to the compression of the spinal cord and nerve roots, can cause lumbar pain, as well as innervation of the lower limbs with pain, numbness and weakness and other symptoms. 3. Vascular lesions: If vascular lesions such as vasculitis of the lower limbs and varicose veins of the lower limbs occur, resulting in obstruction of blood flow to the lower limbs, causing soreness and pain due to muscle ischemia, there may be fatigue in the inner thighs and calf bellies. The appearance of inner thighs and calf stomach feeling tired, there may be other causes, it is recommended that patients seek medical attention in time to clarify the cause of the disease for standardized treatment.