The strongest of the stomach acid inhibiting drugs, mainly proton pump inhibitors, are represented by omeprazole, pantoprazole, rabeprazole, and estramiprazole. Omeprazole is the older drug, and is now slowly being phased out at present. Generally, pantoprazole is used, and also rabeprazole, 20mg at a time, once a day. In case of conditions such as gastric ulcer, it can be used twice a day. Esomeprazole is currently a more advanced acid-suppressing drug, the effect is very strong, proton pump inhibitor is much stronger than H2 receptor antagonist, can achieve the effect of acid suppression, stomach protection.