A slightly hyperechoic nodule in the S6 segment of the liver is a nodule with elevated echoes in the lower right posterior lobe of the liver. Intrahepatic bile duct stones, intrahepatic calcification, etc. are most often considered. Differentiated according to the anatomical landmarks of the liver, hepatic S6 segment refers to the lower segment of the right posterior lobe of the liver, a section defined by the right hepatic vein and the right branch of the portal vein. Slightly hypoechoic nodules are nodules that show elevated echoes different from those of normal liver tissue on imaging, most often intrahepatic bile duct stones, foci of hepatic calcification, and hepatic hemangiomas. However, slightly hyperechoic nodules are not necessarily benign lesions, and some malignant tumors may also present slightly hyperechoic nodules. If slightly hyperechoic nodules are found in the S6 segment of the liver, the cause of the disease should be clarified and the treatment should be standardized under the guidance of the doctor.