Anal fissure according to different therapeutic purposes, can use different drugs, commonly used external rubbing drugs are lidocaine gel paste, nitroglycerin ointment, fibroblast growth factor gel and so on. 1. Lidocaine gel: a local analgesic, anal fissure patients with severe pain, can be coated with lidocaine gel to reduce pain. Adverse effects of lidocaine gel are not clear, pregnant women and those who are allergic to lidocaine hydrochloride are prohibited. 2. Nitroglycerin ointment: anal fissure can be used to reduce the pressure of the anal canal and relieve the pain caused by spasm of the sphincter. Adverse reactions such as headache may occur after use. It is forbidden for those who are allergic to nitrates, hypotension and minors. 3. Fibroblast growth factor gel: mainly help patients with anal fissure to promote wound healing. Individual patients may have a slight tingling sensation after use, allergic to recombinant bovine basic fibroblast growth factor is prohibited. Patients with anal fissure need to be guided by a doctor to use medication, and it is recommended to find the symptoms of anal fissure and consult a doctor in a timely manner.