Lymph node enlargement is particularly painful when sleeping, may be due to local soft tissue infection, reactive hyperplasia, malignant tumors and other diseases. 1. Local soft tissue infection: the patient’s body with a large number of bacterial toxin proliferation, can make the body’s lymphocytes reactive increase, clinical manifestations of the lesion site of redness, swelling, heat, pain and other symptoms, a few patients can be accompanied by fever, blood leukocyte increase and other symptoms. 2. Reactive hyperplasia: Long-term stimulation causes reactive hyperplasia of lymphocytes and histiocytes in the lymph nodes, resulting in enlarged lymph nodes and special pain when sleeping. 3. Malignant tumors: lymph is the way of malignant tumor metastasis, such as gastric malignant tumors, colon malignant tumors can cause intra-abdominal or retroperitoneal lymph node enlargement, appearing special pain when sleeping. The symptoms of enlarged lymph nodes especially painful when sleeping, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, and comply with the doctor’s instructions for treatment, so as not to delay the condition.