18-year-old boy infected with Helicobacter pylori should be treated with oral medication under the guidance of a doctor, and currently the commonly used method is anti-Helicobacter pylori quadruple therapy, i.e. two antibiotics + a proton pump inhibitor + a bismuth agent. 1. Antibiotics: antibiotics play an important role in the treatment process, and should be selected according to the local drug resistance situation. Commonly used antibiotics are: amoxicillin, metronidazole, levofloxacin, tetracycline and so on. 2. Proton pump inhibitors: Proton pump inhibitors can inhibit gastric acid and elevate the pH value in the stomach to make antibiotics work better. Commonly used drugs are omeprazole, rabeprazole and so on. 3. Bismuth: Bismuth is a gastric mucosal protective agent, which can promote mucosal regeneration and ulcer healing. Commonly used drugs are bismuth potassium citrate, colloidal bismuth pectin and so on. In conclusion, in the process of H. pylori treatment, patients should follow the doctor’s instructions and regular review, in addition to paying attention to develop good eating habits.