Immunotherapy for soft tissue sarcoma is less effective and may be effective in only a few patients. Soft tissue sarcoma is a malignant tumor that grows relatively quickly and is highly malignant. It is prone to hematogenous metastasis. Patients are treated with surgical treatments such as wide resection, radical resection, and amputation, as well as radiotherapy, chemotherapy, and targeted drug therapy. Generally immunotherapy is not the first choice of treatment because this type of tumor is not sensitive to immunotherapy, and the effect of immunotherapy is not ideal for most patients, and only a few patients will have some effect. Patients are advised to consult professional doctors to choose the suitable treatment for themselves and have early treatment.