Treatment of chronic urticaria is more difficult compared to acute urticaria. The causes of chronic urticaria are complex and some may be related to chronic gastritis, some may be related to abnormal thyroid function, etc. The persistence of the cause and the difficulty in removing it is one of the possible reasons for the treatment of chronic urticaria. Antihistamine therapy is preferred for the treatment of chronic urticaria. Most people are able to get the condition under control by taking medications regularly, only to treat it for a long time and then slowly reduce the medication, but it is still difficult to avoid recurrence of chronic urticaria. The medication is only to control the symptoms, improve the patient’s standard of living, reduce itching symptoms, etc. Therefore, the treatment of chronic urticaria is more difficult, coupled with the complex causes of chronic urticaria, treatment is mainly symptomatic treatment, not etiological treatment, so it does not achieve a complete cure without recurrence of the effect.