The difference between fire and herpes labialis is different in etiology and clinical manifestations. Fire is the concept of Chinese medicine, mostly related to external evil, dietary factors, mental factors and so on. The main clinical manifestations are redness, swelling, heat, pain and annoyance, which can be categorized into two main categories: real fire and imaginary fire. Herpes labialis is a western medical concept, a skin disease caused by herpes simplex virus infection, characterized by dense blisters on the lips or surrounding skin. The main manifestation is the appearance of dense blisters on the lips or surrounding skin, which later break down and crust. Some patients may be accompanied by fever, malaise, anorexia, sore throat, headache, and muscle aches. If patients experience symptoms of lip discomfort, it is recommended that they go to the hospital as soon as possible to avoid delaying their condition.