Hepatitis B mothers undergo mother-to-child interruption as follows: 1. If there is a possibility of mother-to-child transmission, newborns are immediately injected with hepatitis B vaccine and hepatitis B immunoglobulin within 24 hours after birth. According to the current method, the overall interruption rate is about 95%. 2. The current failure of mother-to-child interruption is often due to intrauterine infection occurring late in pregnancy. There is evidence of increased immunization failure in newborns with high maternal serum load of HBV-DNA (>107). To further reduce the probability of transmission, oral antiviral therapy can be added after 28 weeks of gestation. 3. The application of hepatitis B immunoglobulin in the second trimester is of doubtful use for mother-to-child blockade because the amount is so small as to be almost ineffective. However, if there are conditions, it can be applied in the second trimester, which is not harmful. 4. There is no correlation between normal delivery and caesarean section and the chance of mother-to-child transmission.