If you drink alcohol and accidentally take a cephalosporin, if you have a disulfiram-like reaction, it usually occurs within 5 minutes to 1 hour, but some patients may have a reaction in about 10 hours, so you may still have a reaction after 5 hours. A disulfiram-like reaction occurs when ethanol-containing substances are ingested before or after taking disulfiram medication, and the patient may experience nausea, chest tightness, and difficulty breathing, with the severity being related to the dose of medication and alcohol consumed. Disulfiram-like reaction usually occurs within 5 minutes to 1 hour after the contact between the drug and alcohol. Drinking alcohol accidentally hit the cephalosporin, there is no reaction within 5 hours, and the chances of having a disulfiram-like reaction at a later stage are lower, but it is possible. If nausea, chest tightness, dyspnea and other symptoms occur, you should seek medical treatment in time to avoid delaying the condition, otherwise it may be life-threatening. It is recommended to develop good living habits, do not drink alcohol during the medication period, and avoid medication within 7 days after drinking, especially taking drugs that can cause disulfiram reaction such as cephalosporins, nitroimidazoles, moxifloxacin, etc., to avoid triggering adverse consequences.