There are several drugs that have been found to induce or aggravate psoriasis β-blockers: such as Takeostasis (also known as Protanerol, the most commonly used β-blocker in clinical practice.) ), and antacid (Antacid, Antazoline, Antazoline hydrochloride), can cause a rash similar to psoriasis and make it resistant to therapeutic drugs, making the rash stubborn and difficult to treat. In a group of experiments using guinea pigs as a model, topical agents of antacid were found to trigger a psoriasis-like rash. Antimalarial drugs: antimalarial drugs such as chloroquine, primaquine and hydroxychloroquine can cause hyperpigmentation, erythroderma and palmoplantar keratosis, and aggravate the original psoriasis rash. Lithium metal-containing drugs: lithium carbonate, lithium acetate, lithium citrate, etc. can cause many skin adverse reactions after long-term use, such as skin ulcers, itchy rash, erythrodermatitis, acne-like rash, hair loss, lupus erythematosus, psoriasis, which is more common to induce or aggravate psoriasis. There are reports confirming that lithium has the effect of inhibiting epidermal adenylate cyclase, which reduces CAMP in the body, thus triggering psoriasis. Non-steroidal anti-inflammatory drugs: such as anti-inflammatory pain, pautazone, ibuprofen, isobutyric acid, etc. can cause urticaria, photosensitivity dermatitis, erysipelas, maculopathy, toxic epidermal necrolysis loosening disease and many other skin adverse reactions, which can aggravate the condition for psoriasis and make the rash resistant to treatment. Tetracycline antibiotics: such as tetracycline, doxycycline, minocycline and other drugs have special affinity for the skin, and their concentration is higher than normal skin in psoriatic rashes. One literature observed the effect of tetracycline on psoriasis in 113 cases of psoriasis patients or those with a family history of psoriasis, and the results showed that five people were induced to develop psoriasis. In addition, vaccination, digoxin, amiodarone, potassium iodide, and hair dyes have occasionally caused exacerbation of psoriasis. In conclusion, there are many kinds of drugs that induce or aggravate psoriasis, some of which need to be further observed, studied and confirmed by clinical workers. Clinicians should avoid the use of these drugs that trigger or aggravate psoriasis as much as possible when formulating medication regimens. Psoriasis is a polygenic, genetic skin disease with complex factors involved. Although there are many treatments available, none of them have a curative effect and can only have a near-term effect or prevent recurrence. Therefore, patients should not blindly consult a doctor, and should not use any “one shot” or “imported special drugs” or “ancestral secret recipes” indiscriminately. Although there is no cure for psoriasis, doctors are not completely helpless. If the available therapies can be applied reasonably, it is possible to control or alleviate the symptoms of psoriasis. The primary goal of effective treatment is to clear the lesions and achieve clinical cure within a certain period of time. In addition, psoriasis, especially psoriasis vulgaris, generally has no visceral organic lesions except for skin damage. The presence of this disease does not affect the patient’s other health conditions, let alone reduce one’s life expectancy. Therefore, when choosing a treatment method, it is appropriate to be gentle and not intense; it is appropriate to progress gradually and not to rush to success.