Murphy’s sign is mainly a method to detect cholecystitis. Clinically, if a patient’s Murphy’s sign is positive, it indicates that there is a problem with the gallbladder, mostly seen in patients with acute cholecystitis. Because of the heavy inflammation of the gallbladder, the inflammation spreads to the organs around the gallbladder and the peritoneum, which can manifest as localized peritoneal irritation signs, restricted abdominal breathing, pressure pain in the right upper abdomen or subxiphoid process, and tension or rebound pain in the abdominal muscles, with the gallbladder area being more obvious. Clinically, if Murphy’s sign is positive, it indicates that the inflammation of the gallbladder is relatively severe and requires active anti-infective treatment, it has the risk of gallbladder perforation, so active symptomatic treatment is required, and emergency surgery is needed if necessary.