Under normal circumstances, the level of transaminases in blood is very low. When destructive lesions occur in human liver cells, the transaminases in the cells can be released into the blood, causing an increase in transaminases, so the key to lowering transaminases is to treat the primary lesions, and at the same time use the adjuvant treatment of liver protection and enzyme reduction. Diseases that cause elevated transaminases commonly include viral hepatitis, alcoholic liver disease, fatty liver, cirrhosis, as well as acute myocardial infarction, dermatomyositis and other diseases, which should be promptly improved with hepatitis virus series, liver ultrasound and other related laboratory tests and examinations to clarify the specific causes, and then precise treatment. For example, fatty liver patients can exercise, weight loss and other non-drug therapy; viral hepatitis patients should promptly carry out liver protection, antiviral and other related treatment. In addition, if the aminotransferases are high due to non-pathological reasons such as fever, strenuous exercise, medication, alcohol consumption, etc., no special treatment is needed. In addition, for abnormal liver function and elevated transaminases, we can add some auxiliary drugs to protect liver and lower enzymes, such as silymarin, dicyclomine and other enzyme-lowering drugs or anti-inflammatory and choleretic drugs such as glutathione, ursodeoxycholic acid and glycopyrrolate preparations, which can be used under the guidance of professional physicians. In summary, the key to lowering transaminases is to carry out etiological treatment, and can use liver-protective and enzyme-lowering adjuvant therapy to promote recovery.