Enlarged pores on oily skin can be a symptom of both physiological factors such as overproduction of sebaceous glands and other conditions such as seborrheic dermatitis and acne. Patients can improve their condition through general treatment, medication and physical therapy. 1. Excessive sebaceous gland secretion: Sebaceous glands of patients with oily skin secrete oil more vigorously, and the oil clogs the pores, thus leading to enlarged pores. Patients should pay attention to improve the lifestyle, avoid smoking, drinking, staying up late and other bad habits. In addition, patients should do a good job of skin cleaning and moisturizing work. 2. Seborrheic dermatitis: Seborrheic dermatitis is a chronic inflammatory disease, inflammation will promote local skin differentiation, which will lead to poor keratinization and large pores. Patients with seborrheic dermatitis can use topical tacrolimus ointment, ketoconazole lotion, glycerite lotion and other drugs. Patients with severe symptoms can take oral itraconazole and other drugs. 3. Acne: Acne is a chronic inflammatory disease of the sebaceous glands of hair follicles. Patients with enlarged pores due to acne can use topical medications such as retinoic acid cream and fusidic acid ointment. In addition, patients can also use laser and other physical therapy for symptomatic treatment. It is important to note that all of the above medications should be used under the guidance of a physician. Patients with oily skin with large pores should go to the hospital in time, under the guidance of the doctor to choose the appropriate treatment program.