Babies crying in the middle of the night should pay attention to the following situations: First, whether the environment temperature is comfortable, whether there is insufficient breastfeeding and other phenomena. Second, vitamin D deficiency rickets, not given on time vitamin D supplementation, mostly accompanied by excessive sweating, occipital baldness, irritability and other symptoms, after giving supplemental vitamin D and calcium, will gradually be improved. Third, difficult to raise type temperament, everyone’s temperament is different, inherent. Babies with difficult-to-raise temperament are more difficult to bring up and are prone to crying and restlessness, so they can go to the hospital for temperament assessment and be given early training according to the results. Fourth, sleep dependency disorder. The baby is raised by holding, shaking or sleeping with the nipple on weekdays, and should gradually quit the dependency factors and improve gradually.