The first thing you need to do is to find out the cause of your toothache and then treat it. Painkillers can only provide momentary relief and have no curative effect. Common ones include ibuprofen and indomethacin. They should be taken on medical advice when the pain is unbearable. The most common causes of toothache are wisdom tooth pericoronitis, pulpitis, and apical periodontitis. 1. Wisdom tooth pericoronitis, which often occurs in young people between the ages of 18 and 25, is a painful swelling of the soft tissues around the crown of the tooth due to the blockage of wisdom tooth eruption. If the inflammation affects the chewing muscles, it can cause different degrees of mouth opening restriction, and in severe cases, there can be generalized symptoms such as discomfort, headache, increased body temperature and loss of appetite. At this time you can take tinidazole 0.5g twice a day; ibuprofen 0.3g twice a day. 2. pulpitis, the patient will appear spontaneous pain, night pain, throbbing pain and other symptoms. Emergency treatment for this kind of tooth pain can be ibuprofen 0.3g orally twice a day. The root treatment is to drill the pulp under local anesthesia to drain, and then do the follow-up treatment. 3. Apical periodontitis, caused by further development of pulpitis, bite pain. Anti-inflammatory painkillers can be taken, such as cefadroxil 0.5g 3 times a day; or metronidazole 0.4g, 3 times a day; indomethacin 25mg, 3 times a day. Eat soft food and wait for anti-inflammation before performing root canal treatment. It should be noted that patients with peptic ulcers and those who are allergic to drugs should avoid using the above pain relieving drugs. In the process of treating a toothache, taking medication is only the most minor step, and painkillers are taken only when there is no condition to consult a doctor. All of the above medications should be used under a doctor’s supervision and avoid self-medication.