According to some information, the European Medicines Agency’s Committee on Risk Assessment for Drug Safety Regulation issued a message in March 2014 recommending that drugs containing domperidone be used only for the treatment of nausea and vomiting and can no longer be used for the treatment of bloating and stomach upset, and that doses be restricted for fear of causing adverse cardiac reactions caused by pendolitone, especially for people with existing heart disease who need to be more cautious or contraindicated. Morpholine is a new type of gastric motility drug, mainly used for indigestion symptoms caused by reflux esophagitis, reflux gastritis and chronic gastritis esophagitis, but also for the treatment of nausea caused by a variety of reasons, can promote the peristalsis and tension recovery of the gastrointestinal tract, accelerate gastric emptying. However, because the mechanism of action is different from other gastric drugs, mixed use will instead reduce their pharmacological effects and even increase the enhancement of adverse reactions. However, in reality, because most of the gastric drugs are OTC drugs, and many patients have become a common phenomenon of their own random combination use. Digestive aid drugs such as pepsin combination, multi-enzyme tablets, etc. These drugs have the strongest effect under acidic conditions, such as in combination with domperidone, because domperidone accelerates gastric emptying, so that these drugs quickly enter the intestinal cavity, losing the gastric acid environment, the effectiveness of the drug is reduced. Anticholinergics such as atropine, bromoproterenol, belladonna tablets, etc. These drugs inhibit gastrointestinal peristalsis and delay gastric emptying time, which is the opposite of the pharmacological effect of domperidone, and the combination of the two will cancel each other’s efficacy. Gastric mucosa protective agents such as colloidal bismuth, aluminum thioglycollate, etc.. These drugs can form a protective film in the stomach to protect the stomach wall. If combined with domperidone, also because domperidone accelerates gastric emptying, so that the time for these drugs to form a protective film in the stomach is shortened, reducing the efficacy. Stomach acid neutralizing drugs such as gastropin, sodium bicarbonate tablets, aluminum hydroxide, etc. These drugs can neutralize gastric acid, protect gastric mucosa and repair ulcer surface, so the longer they stay in the stomach, the more adequate the effect of protecting gastric mucosa will be. If combined with domperidone, as domperidone increases gastrointestinal peristalsis, it will shorten the residence time of these drugs in the stomach and make them less effective. Metoclopramide This drug and domperidone are both antiemetic drugs, both can enhance gastrointestinal peristalsis and promote gastric emptying, but the mechanism of action is different. If the two are used together, it will increase the occurrence of drug side effects.