Whether a creatinine value of 110 μmol/L can return to normal depends mainly on the cause of elevated creatinine and cannot be generalized. Elevated creatinine can be categorized into physiological and pathological causes. 1. Physiological causes: creatinine will increase in people who have strenuous exercise, overwork or strength training, and the muscle size is too large, usually creatinine can return to normal gradually after the causative factors are eliminated. 2. Pathological causes: such as pre-renal acute kidney injury, urinary stones, pyelonephrosis and drug-induced renal injury causes creatinine increase, need to be actively treated to remove the cause of the disease, usually creatinine can be restored. In chronic renal failure caused by glomerulonephritis of all types, creatinine elevation occurs mostly due to impaired renal function, which usually cannot be recovered, and it is necessary to actively control blood pressure, blood glucose, blood lipids, and reduce proteinuria, which is helpful to delay the further rise of blood creatinine. If the creatinine is found to be elevated, it is recommended that patients go to the hospital in time to find out the cause and actively cooperate with the doctor for treatment so as to avoid delaying the condition.