Children with fever and red spots on the upper part of the mouth may have herpes labialis, hand, foot, and mouth disease, or candidal stomatitis. Antiviral treatment or antifungal treatment should be carried out for the cause of the disease. 1. Herpes: children with herpes can appear fever, headache and other systemic symptoms, oral mucosa extensive congestion and edema, and then appeared in clusters of small blisters, like the size of a pinhead. 2. Hand, foot and mouth disease: hand, foot and mouth disease is prone to occur in children, is due to coxsackie virus infection caused by the onset of visible mucosal congestion, followed by the emergence of small ulcers and so on. Treatment of the above two diseases is mostly symptomatic, can be used locally interferon nebulizer antiviral, pay attention to oral care, eat a light diet, rest, body temperature over 38.5 ℃, to be ibuprofen and other antipyretic drugs symptomatic treatment. 3. Oral candidiasis: oral candida infection systemic reaction is generally mild, sometimes there is a mild fever, lip and soft palate mucous membrane area colored white like snow small spots, mucosal congestion, treatment using mycobacteria tablets, pay attention to oral care. Children with fever and red spots on the upper part of the mouth and other diseases may, it is recommended to go to the hospital according to the clinical manifestations and laboratory tests, diagnosis and targeted treatment, the use of drugs need to comply with the doctor’s instructions.