Hypothyroidism does not usually lead to weight loss. Instead, people with hypothyroidism can experience weight gain. Hypothyroidism with weight loss may be a normal phenomenon after taking medication, or it may be due to overdose of medication and comorbidities with other diseases, etc. . 1. Normal phenomenon: Some patients with hypothyroidism experience weight gain, and after taking the relevant medication, the edema will subside and weight loss may occur. 2. Drug overdose: patients with hypothyroidism need to take thyroid hormone for treatment, when the dose of therapeutic drugs is inappropriate and cause pharmacological hyperthyroidism, this situation may cause weight loss. 3. Combination of other diseases: certain consumptive diseases, such as diabetes mellitus, malignant tumors, may make hypothyroid patients lose weight. In the clinic, patients with hypothyroidism usually do not experience weight loss, once weight loss occurs, should be vigilant, it is recommended to go to the hospital in a timely manner.