The causes of high uric acid may be inborn metabolic defects, excessive production of uric acid and impaired uric acid excretion. 1. Inborn metabolic defects: inborn metabolic defects may be related to the presence of increased activity of ribulose phosphate pyrophosphate synthase, lack of hypoxanthine-guanine phosphoribosyltransferase, type I glycogenosis, hereditary fructose intolerance and other factors. 2. Excessive production of uric acid: excessive production of uric acid may be related to the patient’s high-purine diet (seafood, animal offal, etc.) and alcohol intake, in addition to lymphoma, multiple myeloma, renal tubular disease and other diseases may also lead to secondary elevation of uric acid. 3. Uric acid excretion disorder: kidney disease, diabetic ketoacidosis, lactic acidosis and other diseases may lead to uric acid excretion disorder. It is recommended that patients with high uric acid go to the endocrinology department or rheumatology department of regular hospitals for detailed consultation.