Itchy blisters on the outside of the ankles (i.e. “blisters”) are caused by eczema, tinea pedis and other factors. 1. Eczema: the cause of the disease is not known, may be related to genetics, infection, allergy, environment, mental psychological factors. Acute eczema may appear on the outside of the ankle red blisters, accompanied by intense itching, tingling and other symptoms, scratching will also lead to local bacterial infection. It is recommended to use topical glucocorticosteroids and oral antihistamines under the guidance of a doctor. 2. Tinea pedis: this is a fungal infection, when invading the skin on the outside of the ankle, blisters may appear on the outside of the ankle, accompanied by itching. After diagnosis, should follow the doctor’s instructions for external antifungal drugs for treatment, such as terbinafine hydrochloride cream, clotrimazole cream and so on. It is recommended that patients with blisters on the outside of the ankles with itching go to a regular hospital in time, after a clear diagnosis under the guidance of a doctor to standardize the treatment, in the process of treatment, must follow the doctor’s advice and reasonable use of medication, do not self-medication.