4 Types of Thyroid Cancer Pathology Presentation

The thyroid gland is a special part of the body located just below the larynx and is a vital organ that is mainly responsible for endocrine secretion. Because this part is very secretive, this part produces cancer and is also known as the human body’s time bomb. So what are the symptoms of thyroid cancer and what are the treatment myths of thyroid cancer? A together to understand the following. Pathological types of thyroid cancer: (1) Papillary adenocarcinoma is the most common type of thyroid cancer, accounting for about 70%. It is the most common type of thyroid cancer, accounting for about 70%. It is generally well differentiated and of low malignancy. The cancerous tissue is brittle, soft and friable with dark red color; however, papillary carcinoma in elderly patients is generally hard and pale. The center of papillary carcinoma often has cystic changes and the capsule is filled with bloody fluid. Sometimes the cancerous tissue may be calcified and the cut surface is sand-like. The above cystic changes and calcification have nothing to do with the malignancy of the carcinoma or its prognosis. Microscopically, the carcinoma is composed of columnar epithelial papillae, sometimes mixed with follicular structures, and even papillary to follicular metaplasia is found. The papillary adenocarcinoma leaves have complete peritoneum, but in the late stage, it can also penetrate the peritoneum and invade the surrounding tissues, and the dissemination pathway is mainly the lymphatic tract, and the cervical lymph node metastasis is the most common one, which can be detected in about 80% of the children and 2% of the adult patients, followed by the blood metastasis to the lungs or the bones. (Follicular adenocarcinoma is less common than papillary adenocarcinoma, accounting for about 20% of thyroid cancers and ranking second, and the average age of its patients is older than that of papillary carcinoma. The cancer is soft, elastic, or rubbery, round, oval or lobulated nodular. The section is reddish brown, and fibrosis, calcification, hemorrhage and necrotic foci can be seen. In well-differentiated follicular adenocarcinoma, the tissue structure is similar to that of normal thyroid gland, but there is invasion of peritoneum, blood vessels and lymphatic vessels; in poorly-differentiated follicular adenocarcinoma, there is irregular structure, and the cells are densely packed into clusters or cords, and follicles are seldom formed. Although lymphatic metastasis is possible, it mainly spreads to lungs, bones and liver through blood. Some follicular adenocarcinomas may recur long after surgical resection, but their prognosis is not as good as papillary adenocarcinoma. (Medullary adenocarcinoma of thyroid accounts for 2-5% of thyroid cancer. It was first described by Hazard in 1959 and is characterized by secretion of thyrocalcitonin and associated with pheochromocyte carcinoma and thyroid gland hyperplasia. Medullary carcinoma originates from the gill posterior body of the thyroid embryo and transforms from parafollicular bright cells (C cells). Parafollicular cells are endocrine cells derived from the neural crest, and these endocrine cells share a common function of uptake of precursors such as 5-hydroxytryptamine and dopamine and decarboxylation by decarboxylase enzymes therein, and so are also referred to as amine precursor uptake decarboxylating cells, or APUD cells for short. The tumors are mostly single nodules, occasionally multiple, hard and fixed, with amyloid deposits, and rarely ingest radioactive iodine. The morphology of cancer cells mainly consists of polygonal and spindle-shaped cells with diverse arrangements. (Undifferentiated carcinoma of the thyroid gland accounts for 5% of thyroid cancers, which mainly occurs in patients above middle age and is more common in males. The mass is hard and irregular, fixed, grows rapidly, and soon diffusely involves the thyroid gland, and usually infiltrates the trachea, muscles, nerves and blood vessels in a short period of time, causing swallowing and dyspnea. The tumor may be localized with tenderness. Microscopically, the cancerous tissue mainly consists of poorly differentiated epithelial cells, with pleomorphic cells and common nuclear schizophrenic phase. Lymph node enlargement may be seen in the neck, and there are also lung metastases. The disease has a poor prognosis and is ineffective for radioactive iodine therapy, and external irradiation only controls local symptoms.