Tumor markers of endometrial cancer mainly include CA125, CA19-9 and CEA, HE4. endometrioid carcinoma sometimes secretes CA125, especially endometrial plasma breast carcinoma, so it shows elevated blood CA125. And endometrioid adenocarcinoma or mucinous adenocarcinoma will secrete CA19-9 and CA125, so it will show as elevated CA19-9 or CA125. Some of the endometrial cancer cells will secrete more CEA, which will show as elevated blood CEA. If there is distant metastasis or in the middle and advanced stages, two markers, CA125 and HE4, will increase. However, tumor markers are not specific. Other cancers may also cause elevation of CA125 and other tumor markers, such as ovarian cancer, sometimes colorectal cancer also shows elevation of CA19-9, and even without any malignant tumor, it may cause elevation of CA125 when fever or cold is present. There are also times when endometrial cancer has occurred but the tumor markers are normal. Therefore, although tumor markers are called tumor markers, they are not the basis for diagnosis of malignancy and there are many false negatives or false positives. Tumor markers are more often used for follow-up observation of tumor, such as after surgery or surgery plus radiotherapy, to determine remission or recurrence based on the decrease or increase of tumor markers. It is very unscientific to judge malignant tumor according to the elevation of tumor markers before surgery, and malignant tumor should be clearly judged according to pathology.