Early Down’s syndrome screening with high risk proves that the patient’s fetus is very likely to have trisomy 21 and trisomy 18, and the patient must pay attention to it. It is recommended that non-invasive genetic testing and amniocentesis be performed for further confirmation during later screening. Non-invasive genetic testing is only a blood test, and the accuracy rate is very high. However, if there is a problem with the NIC test, it cannot be used as a final criterion and the patient needs to undergo amniocentesis for confirmation. Amniocentesis is recommended if the patient wants to be tested in one step. The results of amniocentesis are the most accurate and can also check if the fetus has other diseases, and the results of this test will be the final criterion.