If asymmetric facial puffiness is present, it is associated with multiple diseases and a comprehensive analysis should be performed. The first consideration is the presence of oral disease, such as facial puffiness caused by inflammation of the teeth or gums. If oral diseases are excluded and half of the face is swollen, the possibility of superior vena cava obstruction syndrome should be considered. This is a condition in which compression of the superior vena cava affects venous return and causes half of the face to become swollen. A CT chest examination needs to be completed to find out if there is an occupancy. The occupancy may cause compression and lead to obstruction of the superior vena cava. It is recommended that the patient go to the stomatology department of a regular hospital for examination and treatment, clean the oral hygiene thoroughly, and pay attention to daily oral care. It is recommended to take roxithromycin and tinidazole, and use licorice tablets in water on a daily basis to help the inflammation slowly subside. If the patient has half of the face swollen and no accompanying symptoms, it is recommended to go to the hospital in time to actively search for the cause and carry out appropriate treatment to improve the symptoms.